Hoffmann Bromamide Degradation reaction is shown by __________.


• Hoffmann Bromamide Degradation reaction occurs by treating an amide with bromine in the presence of the aqueous or ethanolic solution of sodium hydroxide.


• In this reaction, migration of an alkyl or aryl group happens from the carbonyl carbon of the amide to the nitrogen atom of the same amide.


• Hence the amine formed contains one carbon less than that of the reactant amide.



(i) ArNH2 (iii) ArNO2 and (iv) ArCH2NH2 do not undergo this degradation reaction.

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