Will geographical isolation be a major factor in the speciation of an organism that reproduces asexually? Why or why not?

No; geographical isolation will not be a factor in the speciation of an organism that reproduces asexually. This is because asexual reproduction is a reproduction wherein an organism does not require another organism to reproduce i.e. there is no fusion of gametes. There is very little variation over generations. Thus, geographical isolation cannot be a major factor in the speciation of an organism that reproduces asexually since variations in DNA are not enough to raise a new species.