The procedure of GIFT involves the transfer of female gamete to the fallopian tube. Can gametes be transferred to the uterus to achieve the same result? Explain.

GIFT – Gamete Intra Fallopian Transfer is one of the methods of Assisted Reproductive Technology (ART). GIFT is transfer of an ovum collected from a donor into the fallopian tube of another female who cannot produce an ovum, but can provide suitable environment for fertilisation.

And if the gametes/ovum is transferred to the uterus, from uterus they cannot move to fallopian tube. And also fertilisation does not take place in uterus as uterine environment is not congenial for the survival of the gametes. Hence the same results cannot be achieved.

And also if gametes are directly transferred to uterus they get degenerated or could be phagocylosed and hence viable zygote is not formed. So, same result is not possible.