Among the five factors that are known to affect Hardy-Weinberg equilibrium, three factors are gene flow, genetic drift and genetic recombination. What are the other two factors?

Five factors are known to affect Hardy-Weinberg equilibrium. These are gene migration or gene flow, genetic drift, mutation, genetic recombination and natural selection.

So the other two factors are mutation and natural selection.

Mutation – is the large difference arising suddenly in a population.

Natural Selection – is a process in which heritable variations enabling better survival are enabled to reproduce and leave greater number of progeny.