Q12 of 70 Page 55

The harmful allele of sickle cell anaemia has not been eliminated from human population. Such afflicted people derive some other benefit. Discuss.

Sickle cell anaemia is a genetic disorder in which Valine is substituted instead of Glutamic Acid in the beta Haemoglobin chain. This mutation leads to the change of RBC’S shape from disc shape to sickle like shape leading to decreased oxygen in the body and the sickle cell trait developed, also makes people less prone to Malaria.


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