Name the enzyme responsible for the RNA genome of HIV to change into DNA genome.

Reverse transcriptase is the enzyme responsible for the RNA genome of HIV to change into DNA genome.

Reverse transcriptase is also known as RNA-directed DNA polymerase. This is an enzyme encoded from the genetic material of retroviruses that catalyzes the transcription of retrovirus RNA (ribonucleic acid) into DNA (deoxyribonucleic acid).