How is the ozone layer depleted?

Various man-made compounds like CFCs, which are carbon compounds having both fluorine and chlorine that are very stable and not degraded by any biological process were found to persist in the atmosphere. Once they reached the ozone layer, they would react with the ozone molecules. This resulted in a reduction of the ozone layer and it is called ozone layer depletion. Recently they have discovered a hole in the ozone layer above the Antartica.