What are the pitfalls that the writer of science fiction mystery must guard against?

According to author, the pitfalls that the writer of science fiction mystery must guard against, as he said in these lines that:

Writing a scientific mystery, then, has its extraordinary pitfalls and difficulties; how much more so the writing of a science fiction mystery. In science fiction, you not only must know your science, but you must also have a rational notion as to how to modify or extrapolate that science. That, however, only means that writing a science fiction mystery is difficult; it does not mean that it is conceptually impossible as John Campbell thought. After all, it is as perfectly possible to cling to the rules of the game in science fiction mysteries as in ordinary ones.