Malarial fever is not caused in a person immediately after introducing the sporozoites by an infected anopheles mosquito. Why?
When female anopheles mosquitoes bite a healthy person, the sporozoites (the infectious stage) are introduced into his body. Sporozoites multiply within the liver cells first and enter the Red Blood Cells (RBC) of man, resulting in the rupture of RBC. This results in the release of toxic substance called haemozoin which is responsible for the chill and high fever, recurring every three to four days.
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