Q5 of 44 Page 35

Describe the life-cycle of plasmodium in man.

The asexual life cycle of Plasmodium occurs in humans. It begins with a bite of an infected female Anopheles mosquito. When these mosquitoes bite a healthy person, the sporozoites of plasmodium present in the salivary glands of female anopheles are introduced into his body. They multiply within the liver cells first and enter the Red Blood Cells (RBC) of man, resulting in the rupture of RBC. This results in the release of toxic substance called haemozoin which is responsible for the chill and high fever, recurring every three to four days.



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