Which bacterium has been used as a clot buster? What is its mode of action.

Bacterium Streptococcus produces an enzyme known as streptokinase is widely used as an anti-clotting agent. It can break down clots and prevent clot associated diseases like heart attacks.

Streptokinase combines with the plasminogen in the blood which forms an activator complex and it converts the plasminogen into plasmin. The plasmin is then able to degrade clot-bound fibrin.