Certain phenotypes in human population are spread over a gradient and reflect the contribution of more than two genes. What is the term used for the types of inheritance? Describe it with the help of an example in human population.
OR
Summarize the process by which the sequence of DNA bases in Human Genome Project was determined using the method developed by Frederick Sanger. Name a free living non-pathogenic nematode who’s DNA has been sequenced.
• Such type of inheritance in which more than two genes contribute for the phenotypic traits of an individual is known as Polygenic Inheritance.
• For example, let’s assume that the skin colour in humans is controlled by three genes, namely A, B and C.
• The dominant genes A, B and C are responsible for imparting dark colour to the skin.
• The recessive genes a, b and c are responsible for light skin colour.
• The genotype with all dominant alleles AABBCC will be darkest skin colour.
• The genotype with all recessive alleles aabbcc will be lightest skin colour.
• Whereas there is another genotype AaBbCc which imparts an intermediate skin colour. This because of the presence of three dominant alleles and three recessive alleles.
OR
• The fragments of the DNA were sequenced using automated DNA sequencers.
• Thus obtained sequences were arranged based on some overlapping sequences present in them.
This alignment of sequences couldn’t be done by humans.
• As a result of this, computer based programs were developed for the purpose of aligning.
• These sequences were annotated and were assigned to each chromosome.
• Thus, the sequence of Chromosome 1 was completed.
• Caenorhabditis elegans was a free living non-pathogenic nematode who’s DNA has been sequenced.
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