(a) How are polygenic inheritance and multiple allelism different ? Explain with the help of an example each.
(b) List the criteria a chemical molecule must fulfil to be able to act as a genetic material.
OR
State the hypothesis proposed by Oparin and Haldane. How was it experimentally proved by S.L. Miller ? Explain.
(a) Polygenic Inheritance: In this, traits are controlled by three or more genes (multiple genes). These traits are called polygenic traits. The phenomenon shows participation of each allele. Example: For example, human skin colour which is caused by a pigment melanin. The quantity of melanin is due to three pairs of polygenes (A, B and C). If a black or very dark (AABBCC) and white or very light (aabbcc) individuals marry each othe1, the offsprings show intermediate colour also called mulatto (AaBbCc).
Multiple allelism: When more than two alternative forms (allele) of a gene occupy the same locus on a chromosome in a population, these are known as multiple alleles. The ABO blood grouping is a good example of multiple alleles.
(b) The criteria basis which a chemical molecule can act as a genetic material are:
(i) It should be able to generate its replica or carry out replication.
(ii) It should chemically and structurally be stable.
(iii) It should provide the scope for slow changes or mutations essential for evolution.
(iv) It should be able to express itself in the form of 'Mendelian Characters’.
OR
Oparin and Haldane proposed the hypothesis that the first form of life might have come from pre-existing non-living organic molecules and that formation of life was preceded by chemical evolution. They said that the conditions on earth were – high temperature, volcanic storms, reducing atmosphere which contained CH4 (methane) , NH3 (ammonia), etc.
In 1953, this was experimentally proved by Miller who created similar conditions in a laboratory. He created electric discharge in a closed flask containing CH4 , H2 , NH3 and water vapour at 8000 degrees. He observed that amino acids were formed.

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