Q9 of 71 Page 41

What would happen if histones were to be mutated and made rich in acidic amino acids such as aspartic acid and glutamic acid in place of basic amino acids such as lysine and arginine?

If histones were to be mutated and made rich in acidic amino acids such as aspartic acid and glutamic acid in place of basic amino acids such as lysine and arginine. This mutation would make the histones acidic and negatively charged in nature and histones would not be able to bind to DNA because both would be negatively charged. Hence, the DNA would not be packed and chromatin would not be formed.


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