Q13 of 71 Page 41

A single base mutation in a gene may not ‘always’ result in loss or gain of function. Do you think the statement is correct? Defend your answer.

The above statement is correct. It is because if mutation takes place at the third base pair, it does not lead to a phenotypic change. These mutations are known as silent mutations. If the mutations take place at any other base than the third base phenotypic changes may take place. Forexample: Substitution of Valine instead of Glutamic acid in the beta haemoglobin chain of the RBC’S leads to sickle cell anaemia.


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